New findings show scope of postpartum depression
June 16, 2014 10:40 AM

Postpartum depression isn’t always postpartum. It isn’t even always depression. A fast-growing body of research is changing the very definition of maternal mental illness, showing that it is more common and varied than previously thought.

Scientists say new findings contradict the longstanding view that symptoms begin only within a few weeks after childbirth. In fact, depression often begins during pregnancy, researchers say, and can develop any time in the first year after a baby is born.

Recent studies also show that the range of disorders women face is wider than previously thought. In the year after giving birth, studies suggest, at least 1 in 8 and as many as 1 in 5 women develop symptoms of depression, anxiety, bipolar disorder, obsessive-compulsive disorder or a combination. In addition, predicting who might develop these illnesses is difficult, scientists say. While studies are revealing clues as to who is most vulnerable, there are often cases that appear to come out of nowhere.

As public awareness has grown, often spiking after a mother kills herself or her baby, a dozen states, including Illinois, New Jersey, Texas and Virginia, have passed laws encouraging screening, education and treatment, and New York and others are considering action. The federal Affordable Care Act contains provisions to increase research, diagnosis and care for maternal mental illness.

Sometimes cases are mild, resolving themselves without treatment. But a large analysis of 30 studies estimated that about a fifth of women had an episode of depression in the year after giving birth, about half of them with serious symptoms.

Jeanne Marie Johnson, 35, of Portland, Ore., had a happy pregnancy, but she began having visions right after her daughter, Pearl, was born. She said in an interview that she imagined suffocating her while breast-feeding, throwing her in front of a bus, or “slamming her against a wall.”

She said she was horrified at the idea of hurting her baby, and did not carry out the acts she envisioned. Yet while overlooking a shopping mall skating rink, “I pictured myself leaning over the bridge and letting her fall and bust like a watermelon,” she said. “I was actively thinking of ways to harm her.”

Most women experiencing such “intrusive thoughts,” as experts call them, never hurt their children. Some take extreme measures to protect their babies. One woman “scooched downstairs on her butt for months because she’d imagined throwing her baby downstairs,” said Wendy N. Davis, executive director of Postpartum Support International.

But studies indicate that maternal stress may undermine women’s ability to bond with or care for their children, and that children’s emotional and cognitive health may suffer as a result.

A complex interplay of genes, stress and hormones causes maternal mental illness, scientists say. “Hormones go up more than a hundredfold,” said Dr. Margaret Spinelli, director of the Women’s Program in Columbia University’s psychiatry department. After birth, hormones plummet, a roller coaster that can “disrupt brain chemistry,” she said.

Some women are genetically predisposed to react intensely to hormone changes. And some are more sensitive to stresses like difficulties with family, finances, childbirth or parenting.

Depression in pregnancy can be missed because symptoms like trouble sleeping and moodiness also occur in pregnant women who are not depressed. And doctors have historically been taught in medical school that “women don’t get depressed during pregnancy because they are happy,” said Dr. Katherine L. Wisner, a professor of psychiatry and obstetrics at Northwestern University.

In a 2013 study, the largest screening of women for postpartum depression to date, Wisner and colleagues found that 14 percent of 10,000 women had depression four to six weeks after birth, but that for a third of them it started during pregnancy.

Other research indicated that symptoms could emerge any time in the first year.

Another 2013 study assessed 461 women at two weeks and six months postpartum, and it found each time that 11 percent had obsessive-compulsive symptoms, about four times the rate for the general population of women. But it was “not the same 11 percent,” said an author, Dr. Dana Gossett, chief of gynecology and obstetrics at Northwestern. “Half got better by six months and another half developed OCD.”

Research also shows that women can have several psychiatric disorders at once. In Wisner’s study, two-thirds of the women with depression also exhibited anxiety; nearly a quarter had bipolar disorder.

Tina Duepner, 34, of DeSoto, Mo., had symptoms ranging from racing thoughts to suicidal feelings. She said she heard God’s voice from a television, and other voices warning that her son, Landon, would be stolen from her.

She said stress in her life included a previous miscarriage, premature labor requiring bed rest, and a cesarean section.

Duepner said she was treated successfully, although she required three short psychiatric hospitalizations. She wanted more children, but said doctors advised against it so she had her tubes tied.

Previous depression puts women at greatest risk of maternal mental illness. Having immediate relatives with bipolar disorder also increases vulnerability. Duepner did not have prior depression. But her mother, Marie Carr, has bipolar disorder, and both maternal grandparents had psychiatric illnesses, Carr said.

Financial strain, isolation, breast-feeding difficulties or unplanned pregnancy can also increase risk.

The Second Son

Emily Guillermo, 23, of Horizon City, Texas, had a smooth, joyous experience with her first child, even though her husband spent three months deployed with the Army in Iraq and watched Christopher’s birth on Skype.

“It felt very natural to become a mother to him,” she said.

Then, despite using contraception, she conceived again. Overwhelmed, she said she and her husband agreed to abort but reconsidered after learning she was 20 weeks pregnant. She said she descended into depression during pregnancy, feeling “like my body had been invaded.”

When Benjamin was born, six weeks premature, Guillermo recalled thinking, “You’re not supposed to be mine. You were not supposed to be made.”

She had loved breast-feeding Christopher, but pumped milk for Benjamin. “I could not stand to have him at my chest,” she said. “I was like a robot. I changed him, I fed him, I burped him. Because I never held him, he started to get a flat head.”

She fantasized about abandoning Benjamin at a fire department, or faking an accident. She imagined driving at high speed into a wall, sparing Christopher’s life by intentionally wrecking the side of the car where Benjamin was strapped into a car seat.

Postpartum disorders can involve more intense visions than mental illnesses unrelated to childbirth, Wisner said.

Terrified she might hurt Benjamin, Guillermo said she thought about finding a family to adopt him. One night, “I just blurted out, ‘I don’t love Benjamin.’” She said her husband, stunned, assured her they would get her help, and said, “Until then, I will love him enough for both of us.”

Her first medication failed. Once, she forcibly shut Benjamin’s jaw when feeding him. During several baths, “I held the water over his face until he started to flail, he could not breathe,” she said. “I was hearing a voice saying, ‘Do it and he will stop crying. He’s not going to wake Christopher from his nap.’”

Something would make her stop and put him in his crib. But for a few seconds, she could not remember “if I had killed him, or if he had drowned, or what I had done,” she said. Benjamin became frightened. “When I’d walk into his room, he’d burst into tears.”

Suicidal, she tried to jump from a car as her husband drove, their sons in back, but she said he stopped her, telling her: “You will love Benjamin. We just need to get you on the right medication.”

The third drug combination she tried worked when Benjamin was 9 months old. She started feeling love toward him, and with Postpartum Support International’s help, worked to improve their relationship.

She said his development had regressed. Instead of distinct cries for hunger or sleepiness, he reverted to “one hysterical cry because he had grown accustomed to me taking my time to meet his needs.”

Benjamin is now 21 months old, and his development is back on track. “He still has a long way to go with me,” she said. “I’m his mother now, and he knows that, and I think Benny loves me now too.”

State Legislatures Respond

As more states pass laws relating to postpartum depression, the hope is to catch problems early. Symptoms are frequently treatable, though finding effective medication or therapy can take time.

Only New Jersey requires screening under a 2006 law championed by Mary Jo Codey, then the state’s first lady, who had had postpartum depression. That mandate has drawn mixed reviews. A study in New Jersey of poor women on Medicaid found that required screening has not resulted in more women being treated. Katy Kozhimannil, a University of Minnesota public health professor and an author of the study, said the law educated pediatricians and obstetricians, but did not compensate them for screening.

There are also not enough treatment options, Kozhimannil said. “If a woman comes with a baby, and it’s a place treating people with substance abuse or severe mental illness, she may be uncomfortable.”

In New York, state Sen. Liz Krueger has introduced a bill to encourage screening and treatment, a proposal that will most likely pass and be approved by Gov. Andrew M. Cuomo, who vetoed a 2013 bill on technical grounds but encouraged the revised legislation.

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